PXD065302

PXD065302 is an original dataset announced via ProteomeXchange.

Title	Multi-dimensional Proteomics Reveal Metformin's Impact on Interconnected Regulatory Networks of Protein Turnover, Ubiquitination, DNA Damage, and Cell Cycle
Description	In this study, we investigated the impact of metformin on the cellular ubiquitinome and associated protein turnover. Through an integrated analysis combining ubiquitinome profiling with pulsed metabolic labeling, we found that metformin markedly suppresses global protein ubiquitination, including various types of ubiquitin chain linkages, and concurrently inhibits both protein synthesis and degradation.
HostingRepository	iProX
AnnounceDate	2025-09-26
AnnouncementXML	Submission_2026-01-26_23:35:59.252.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianlong Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Q Exactive HF; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-22 23:09:04	ID requested
⏵ 1	2026-01-26 23:36:00	announced

Wang Z, Li J, Duan J, Shan B, Zhang Y, Multidimensional Proteomics Reveal Metformin's Impact on Interconnected Regulatory Networks of Protein Turnover, Ubiquitination, DNA Damage, and Cell Cycle. Mol Cell Proteomics, 24(12):101440(2025) [pubmed]

submitter keyword: Metformin, Proteostasis, Ubiquitinome, DNA damage repair, Cell cycle

Yaoyang Zhang
contact affiliation	Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
contact email	zyy@sioc.ac.cn
lab head
Jianlong Li
contact affiliation	Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
contact email	lijianlong@sioc.ac.cn
dataset submitter

iProX dataset URI