PXD065260

PXD065260 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adult Ascaris excretory/secretory antigens in pigs
Description	Roundworm infections result in morbidity, causing significant health and economic concerns in humans and pigs, respectively. We investigated the humoral responses of A. suum infected pigs before and after transition from larval to adult stage and confirmed our previous report on the diagnostic value of human Ascaris-specific antibodies. We evaluated the systemic and mucosal humoral responses in Ascaris infected pigs at 14- and 35-days post-infection (dpi). Ascaris-specific antibodies against larval and adult worm antigens and adult excretory/secretory (ES) products in serum, broncho-alveolar lavage fluid and intestinal mucus were quantified by ELISA. IgA+ B cells in jejunal/ileal mesenteric lymph nodes (mLNs) were investigated using flow cytometry.
HostingRepository	MassIVE
AnnounceDate	2025-06-20
AnnouncementXML	Submission_2025-06-20_04:11:54.001.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benjamin-Florian Hempel
SpeciesList	scientific name: Ascaris suum; common name: pig roundworm; NCBI TaxID: 6253;
ModificationList	Carbamidomethyl
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-20 03:56:47	ID requested
⏵ 1	2025-06-20 04:11:54	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Ascaris, Antibody, IgA, Somatic Antigens, DatasetType:Proteomics

submitter keyword: Ascaris, Antibody, IgA, Somatic Antigens, DatasetType:Proteomics

Contact List

Susanne Hartmann
contact affiliation	Freie University Berlin
contact email	susanne.hartmann@fu-berlin.de
lab head
Benjamin-Florian Hempel
contact affiliation	Freie University Berlin
contact email	benjamin.hempel@fu-berlin.de
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098272/