PXD065185 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting Menin in T-Lineage Acute Lymphoblastic Leukemia |
| Description | The efficacy of menin inhibition was evaluated in 14 primary T-ALL samples with diverse genetic backgrounds using ziftomenib. Sensitivity was not correlated with HOXA expression or KMT2A rearrangements, and in vivo treatment significantly reduced tumor burden in xenograft models without notable toxicity. Transcriptomic and proteomic analyses confirmed on-target activity, including downregulation of menin targets and activation of differentiation pathways. Phosphoproteomic profiling identified phospho-MEF2C (S222) as a key marker of sensitivity, regulated by CDK and MAPK signaling. Combination treatment with ziftomenib and CDK1/2 or ERK1/2 inhibitors showed synergistic effects, suggesting a mechanistic link between menin inhibition and p-MEF2C–driven T-ALL vulnerability. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-05 |
| AnnouncementXML | Submission_2026-03-05_10:25:20.577.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Diren Arda Karaoglu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-18 17:12:45 | ID requested | |
| ⏵ 1 | 2026-03-05 10:25:21 | announced | |
Publication List
| 10.1158/1535-7163.mct-25-0969; |
| Shimamoto K, Karaoglu DA, Arnold O, Dhar A, Chan Z, Giordano G, Cheng JX, Youshanlouei HR, Patel AA, DuVall AS, Drazer MW, Kessler L, Burrows F, Odenike O, Thirman MJ, Stock W, Saygin C, Targeting menin in T-lineage acute lymphoblastic leukemia. Mol Cancer Ther, ():(2026) [pubmed] |
Keyword List
Contact List
| Caner Saygin |
|---|
| contact affiliation | Assistant Professor of Medicine Committee on Cancer Biology The University of Chicago |
| contact email | caner.saygin@bsd.uchicago.edu |
| lab head | |
| Diren Arda Karaoglu |
|---|
| contact affiliation | The University of Chicago |
| contact email | ardakaraoglu96@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD065185 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065185
- Label: PRIDE project
- Name: Targeting Menin in T-Lineage Acute Lymphoblastic Leukemia
