PXD065182

PXD065182 is an original dataset announced via ProteomeXchange.

Title	Activation of a bacterial immunity protein by a viral-host factor complex (HDX-MS)
Description	Bacteria have developed sophisticated immune systems to defend against phages, often activating these defenses by detecting specific phage components. In our study, we show that the bacterial defense protein CapRelEbc is activated by a complex between a T7 phage protein (Gp0.4) and the host’s cell division protein FtsZ during infection. Here, we tried to validate this hypothesis by performing HDX-MS.
HostingRepository	PRIDE
AnnounceDate	2026-04-29
AnnouncementXML	Submission_2026-04-29_02:32:34.966.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kyo Coppieters
SpeciesList	scientific name: Escherichia coli (strain B / BL21); NCBI TaxID: NEWT:511693;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-18 16:13:02	ID requested
⏵ 1	2026-04-29 02:32:35	announced

Dataset with its publication pending

submitter keyword: HDX-MS, anti-phage defense

Chloé Martens
contact affiliation	Chloé Martens, Ph.D Chercheuse Qualifiée - FRS.FNRS Group Leader Structure and Function of Biological Membranes - Chemistry Department chloemartenslab.com - sfmb.ulb.be Phone :+32 2 650 53 83 Université Libre de Bruxelles - Campus Plaine. Building BC, Room 1C4 110 - Boulevard du Triomphe, Accès 2 1050 Brussels - Belgium (lab head)
contact email	chloe.martens@ulb.be
lab head
kyo Coppieters
contact affiliation	Université Libre de Bruxelles
contact email	coppieterskyo@hotmail.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065182

PRIDE project URI

• PRIDE
  1. PXD065182
     1. Label: PRIDE project
     2. Name: Activation of a bacterial immunity protein by a viral-host factor complex (HDX-MS)