PXD065104

PXD065104 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis using 4D-FastDIA in gastric cancer cells before and after loss-of-function mutation of STAT1-K193 lactylation.
Description	In this study, we identified a significant lactylation modification at lysine 193 (K193) of STAT1 in gastric cancer tissues through an integrated proteomic and lysine lactylome analysis. Functional assays revealed that the loss of STAT1-K193 lactylation (STAT1-K193la) markedly suppresses gastric cancer cell proliferation, invasion, and metastatic potential. To further elucidate the downstream mechanisms mediated by STAT1-K193 lactylation, we aim to perform comparative proteomic profiling between wild-type STAT1 and the K193 lactylation-deficient mutant. This approach will help identify candidate effector proteins or signaling pathways regulated by STAT1-K193la, which will be subjected to further functional and mechanistic validation to better understand their roles in gastric tumor progression.
HostingRepository	PRIDE
AnnounceDate	2025-09-05
AnnouncementXML	Submission_2025-09-05_05:45:34.697.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Duanrui Liu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-17 02:47:20	ID requested
⏵ 1	2025-09-05 05:45:35	announced

Dataset with its publication pending

submitter keyword: proteomic analysis;4D-FastDIA;gastric cancer

STAT1

lactylation

Duanrui Liu
contact affiliation	Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University
contact email	liuduanrui@foxmail.com
lab head
Duanrui Liu
contact affiliation	Shandong Provincial Hospital
contact email	liuduanrui@foxmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD065104
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis using 4D-FastDIA in gastric cancer cells before and after loss-of-function mutation of STAT1-K193 lactylation.