PXD065028 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TIM-3 Inhibition Enhances Tumor Progression and Metastasis: A Paradoxical Immune Checkpoint Response |
| Description | Syngeneic breast tumors were developed by inoculating of 4T1 cells, into the left flank of female Balb/c mice. When tumor volume reached 200-250 mm3, mice were selected randomized way to receive the treatment of anti-TIM-3 monoclonal antibody (mAb) (Clone: RMT3-23, BioXcell, cat. # BE0115, RRID: AB_10949464). Anti-TIM-3 mAb (250 µg/injection) was administered via the intraperitoneal (i.p.) route. Primary tumors were allowed to developed for up-to 40 days. Primary tumor histology, liver metastasis, and serum cytokine and tumor tissue proteome were analysed and compared between the control tumor and TIM-3 antibody treated tumor. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-29 |
| AnnouncementXML | Submission_2025-12-28_16:42:31.513.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | ANUPAM BASU |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-15 06:35:30 | ID requested | |
| ⏵ 1 | 2025-12-28 16:42:32 | announced | |
Publication List
| Dolui B, Majumdar B, Bandyopadhyay A, Desai KV, Basu A, TIM-3 inhibition enhances breast tumor progression and metastasis: A paradoxical immune checkpoint response. J Biol Chem, 302(2):111096(2025) [pubmed] |
| 10.1016/j.jbc.2025.111096; |
Keyword List
| submitter keyword: TNBC, Brest, LC-MS, Mice, tumor,TIM-3 |
Contact List
| ANUPAM BASU |
|---|
| contact affiliation | Group Leader, Professor, Department of Zoology, University of Burdwan |
| contact email | abasu@zoo.buruniv.ac.in |
| lab head | |
| ANUPAM BASU |
|---|
| contact affiliation | THE UNIVERSITY OF BURDWAN |
| contact email | abasu@zoo.buruniv.ac.in |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD065028 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065028
- Label: PRIDE project
- Name: TIM-3 Inhibition Enhances Tumor Progression and Metastasis: A Paradoxical Immune Checkpoint Response
