PXD065003 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons-APEX2 proteome analysis |
| Description | We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted axonal proteome analysis of a subcluster within vulnerable Aldh1a1+ dopamine axons, defined by Annexin 1 (Anxa1+), confirmed subtle proteomic changes across comparisons |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-19 |
| AnnouncementXML | Submission_2026-05-18_18:01:55.950.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuyu Chen |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | biotinylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-13 10:07:45 | ID requested | |
| ⏵ 1 | 2026-05-18 18:01:56 | announced | |
Publication List
| 10.1101/2025.08.28.672006; |
| Chen C, He Q, Tombesi G, Napier E, Jaconelli M, Moreno-Ramos OA, Serio H, Naaldijk Y, Promes V, Schneeweis A, Quinn K, Nasios C, Greggio E, Kozorovitskiy Y, Arango D, Khan AR, Alessi DR, Dombeck DA, Hilfiker S, Awatramani R, Parisiadou L, Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons. bioRxiv, ():(2025) [pubmed] |
Keyword List
| submitter keyword: lrrk2, APEX2, proteome analysis |
Contact List
| Loukia Parisiadou |
|---|
| contact affiliation | Department of Pharmacology, Northwestern University, Chicago, IL, USA. |
| contact email | loukia.parisiadou@northwestern.edu |
| lab head | |
| Chuyu Chen |
|---|
| contact affiliation | Northwestern university |
| contact email | chuyu.chen@northwestern.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065003 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065003
- Label: PRIDE project
- Name: The Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons-APEX2 proteome analysis
