PXD064944

PXD064944 is an original dataset announced via ProteomeXchange.

Title	BCL7A’s Arginine Anchor Links Nucleosome Recognition to Chromatin Remodeling and DLBCL Tumor Suppression
Description	The N-terminal α-helix of BCL7A, a non-catalytic subunit, exhibits characteristic positive charge distribution. To delineate its contribution to chromatin remodeling and gene regulation, we engineered an N-terminal deletion and performed functional comparisons with wild-type BCL7A in chromatin remodeling assays.
HostingRepository	PRIDE
AnnounceDate	2026-06-08
AnnouncementXML	Submission_2026-06-07_16:08:33.543.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jingdong Xue
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-12 08:26:06	ID requested
⏵ 1	2026-06-07 16:08:34	announced

Xue J, Tian K, Xu X, Feng Y, Yu M, Hao M, Hu M, Wang W, Ma J, Pan Y, Peng M, Wu J, He S, Chen X, Xu Y, Wang W, Lao Y, Li B, chromatin remodeling and diffuse large B-cell lymphoma tumor suppression. Protein Cell, 17(5):452-470(2026) [pubmed]

10.1093/procel/pwaf114;

submitter keyword: cBAF, human SWI/SNF,Chromatin remodeling complex, BCL7A

Bing Li
contact affiliation	Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China
contact email	bingli@shsmu.edu.cn
lab head
Jingdong Xue
contact affiliation	Shanghai Jiaotong University School of Medicine
contact email	j.d.xue@sjtu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD064944

PRIDE project URI

• PRIDE
  1. PXD064944
     1. Label: PRIDE project
     2. Name: BCL7A’s Arginine Anchor Links Nucleosome Recognition to Chromatin Remodeling and DLBCL Tumor Suppression