PXD064913 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative Proteomic Analysis of Porphyromonas gingivalis challenged Human Dental Pulp Stem Cells |
| Description | Dental pulp stem cells (DPSCs) are increasingly recognised for their potential in regenerative medicine, particularly in oral and maxillofacial surgeries. However, the unique microbial environment of the oral cavity necessitates a better understanding of how bacterial challenges may affect DPSC function to optimise their reparative capabilities and potential clinical/therapeutic use. This study focused on identifying and understanding differentially expressed proteins in response to Porphyromonas gingivalis challenge and utilises comparative proteomic methodology of the secretome and whole cell lysates with deeper analysis of differentially expressed proteins using STRINGDB and REACTOME databases to elucidate key proteins and networks. This study identified significant proteomic changes in human DPSCs in response to Pg infection, particularly in growth factor signalling, immune response, and wound healing. These insights advance our understanding of DPSC-pathogen interactions, promoting their potential for regenerative and immunomodulatory therapies against infection |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-21 |
| AnnouncementXML | Submission_2025-11-20_16:27:47.620.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ching-Seng Ang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-11 22:43:14 | ID requested | |
| ⏵ 1 | 2025-11-20 16:27:48 | announced | |
Publication List
Keyword List
| submitter keyword: Secretome proteomic analysis, Regenerative therapy,Dental Pulp Stem Cells, DPSC-pathogen interactions, Porphyromonas gingivalis infection |
Contact List
| Rachael L Moses |
|---|
| contact affiliation | Melbourne Dental School, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Melbourne, Australia |
| contact email | rachael.moses@unimelb.edu.au |
| lab head | |
| Ching-Seng Ang |
|---|
| contact affiliation | University of Melbourne |
| contact email | cang@unimelb.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD064913 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064913
- Label: PRIDE project
- Name: Comparative Proteomic Analysis of Porphyromonas gingivalis challenged Human Dental Pulp Stem Cells
