PXD064879

PXD064879 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of skeletal muscle of DMD, BMD and WT pigs
Description	Duchenne muscular dystrophy is a fatal X-linked disease caused by mutations in the DMD gene, leading to the absence of dystrophin and progressive degeneration of skeletal and cardiac muscles. Pigs lacking DMD exon 52 (DMDΔ52) are a clinically severe model for DMD, mimicking molecular, functional, and pathological hallmarks of the human disease. Dystrophin expression can be restored by additionally deleting exon 51 (DMDΔ51-52), which reframes DMD transcripts and alleviates pathological alterations. DMDΔ51-52 pigs model Becker muscular dystrophy (BMD), a milder and slower-progressing form of muscle degeneration.
HostingRepository	PRIDE
AnnounceDate	2026-03-12
AnnouncementXML	Submission_2026-03-12_04:36:30.140.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jan Bernd Stöckl
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-11 06:54:47	ID requested
⏵ 1	2026-03-12 04:36:31	announced

10.1002/jcsm.70084;

Blasi M, Hristov H, St, ö, ckl JB, Kraetzl M, Fiedler S, Kemter E, Kurome M, Kessler B, Cambra JM, Zakhartchenko V, Walter MC, Kupatt C, Klymiuk N, Fr, ö, hlich T, Blutke A, Stirm M, Jaudas F, Wolf E, 51-52). J Cachexia Sarcopenia Muscle, 16(5):e70084(2025) [pubmed]

submitter keyword: duchenne muscular dystrophy, pig model, becker muscular dystrophy, muscle

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Jan Bernd Stöckl
contact affiliation	Genzentrum der LMU München
contact email	stoeckl@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD064879

PRIDE project URI

• PRIDE
  1. PXD064879
     1. Label: PRIDE project
     2. Name: Proteome analysis of skeletal muscle of DMD, BMD and WT pigs