PXD064759

PXD064759 is an original dataset announced via ProteomeXchange.

Title	Multi-omics single-cell atlas reveals kidney-infiltrating S100A8/A9-high neutrophils as pioneer cells driving fatal urosepsis
Description	We developed a novel Sepsis-Related Death (SRD) rat model that replicates urosepsis progression. We performed multi-omics analysis (transcriptomics, proteomics, and metabolomics) on early septic kidney tissues, followed by comprehensive single-cell RNA sequencing of kidney tissues at different disease stages. We validated key findings using immunohistochemistry, immunofluorescence, large-scale public dataset integration, and analysis of clinical samples.
HostingRepository	iProX
AnnounceDate	2025-06-08
AnnouncementXML	Submission_2025-06-09_00:25:19.612.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhenglin Chang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-09 00:25:01	ID requested
⏵ 1	2025-06-09 00:25:20	announced

Dataset with its publication pending

submitter keyword: AP-1 complex members, urosepsis, single-cell RNA sequencing, dendritic cells, proximal tubular cells, sepsis-related death, neutrophil subpopulations, kidney injury

Baoqing Sun
contact affiliation	Department of Clinical Laboratory, the First Affiliated Hospital of Guangzhou Medical University
contact email	sunbaoqing@gzhmu.edu.cn
lab head
Zhenglin Chang
contact affiliation	Department of Urology, the First Affiliated Hospital of Guangzhou Medical University
contact email	1004720959@qq.com
dataset submitter

iProX dataset URI