PXD064757

PXD064757 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic profiling of DLAT-interacting proteins in cisplatin-resistant lung cancer cells
Description	This study aimed to identify potential protein-binding partners of mitochondrial DLAT that contribute to cisplatin resistance in lung cancer. We performed an unbiased proteomic screen by immunoprecipitating DLAT from cell lysates of A549cisR cells, followed by LC-MS/MS analysis. The analysis identified MTHFD2 among other candidates as a DLAT-interacting protein. These findings provide mechanistic insight into DLAT-mediated chemoresistance.
HostingRepository	PRIDE
AnnounceDate	2025-10-14
AnnouncementXML	Submission_2025-10-14_07:43:52.482.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD064757
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jung Seok Hwang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-08 23:08:06	ID requested
1	2025-08-03 20:17:55	announced
⏵ 2	2025-10-14 07:43:53	announced	2025-10-14: Updated project metadata.

Publication List

10.6019/PXD064757;
10.1038/S41467-025-63892-3;

10.6019/PXD064757;

10.1038/S41467-025-63892-3;

Keyword List

submitter keyword: cisplatin resistance, protein interaction, immunoprecipitation,DLAT, A549cisR, LC-MS/MS

submitter keyword: cisplatin resistance, protein interaction, immunoprecipitation,DLAT, A549cisR, LC-MS/MS

Contact List

Sumiin Kang
contact affiliation	Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
contact email	suminkang@emory.edu
lab head
Jung Seok Hwang
contact affiliation	Emory Winship Cancer Institute
contact email	jhwan30@emory.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD064757
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD064757

PRIDE project URI

Repository Record List

[ + ]