PXD064711
PXD064711 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-Omics Analysis Reveals the Role of Omental Adipose Tissue in Gastric Cancer Peritoneal Metastasis and Identifies Potential Therapeutic Targets |
| Description | Gastric cancer (GC) is a globally prevalent malignancy with a high propensity for peritoneal metastasis (GCPM), which is associated with a poor prognosis. The omentum, particularly its adipose tissue, plays a critical role in GCPM, but the underlying mechanisms are not fully elucidated. We conducted a multi-omics study, integrating lipidomics, proteomics, and metabolomics, using a co-culture system of omentum adipocytes and gastric cancer cells to investigate the molecular mechanisms of GCPM and identify therapeutic targets. Our analysis identified differentially expressed transcripts, proteins, and metabolites implicated in lipid metabolism and other biological processes. Functional enrichment analysis highlighted the involvement of these molecules in pathways such as fatty acid metabolism and phospholipid metabolism. A ceRNA network was constructed to reveal non-coding molecular regulatory mechanisms. Integrative analysis pinpointed core genes, proteins, metabolites, and potential biomarkers AGPAT2, HACD1, and ME1, which were significantly associated with GC prognosis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-06-06 |
| AnnouncementXML | Submission_2025-06-06_01:03:19.952.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lei Yang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-06 01:02:53 | ID requested | |
| ⏵ 1 | 2025-06-06 01:03:20 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Gastric cancer, Peritoneal metastasis, Omental adipose tissue, Multi-omics, Biomarkers |
Contact List
| Chen Chai | |
|---|---|
| contact affiliation | The People’s Hospital of Suzhou New District (SND) |
| contact email | chasechai@126.com |
| lab head | |
| Lei Yang | |
| contact affiliation | The First Hospital of Lanzhou University |
| contact email | yl41023@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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