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PXD064711

PXD064711 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-Omics Analysis Reveals the Role of Omental Adipose Tissue in Gastric Cancer Peritoneal Metastasis and Identifies Potential Therapeutic Targets
DescriptionGastric cancer (GC) is a globally prevalent malignancy with a high propensity for peritoneal metastasis (GCPM), which is associated with a poor prognosis. The omentum, particularly its adipose tissue, plays a critical role in GCPM, but the underlying mechanisms are not fully elucidated. We conducted a multi-omics study, integrating lipidomics, proteomics, and metabolomics, using a co-culture system of omentum adipocytes and gastric cancer cells to investigate the molecular mechanisms of GCPM and identify therapeutic targets. Our analysis identified differentially expressed transcripts, proteins, and metabolites implicated in lipid metabolism and other biological processes. Functional enrichment analysis highlighted the involvement of these molecules in pathways such as fatty acid metabolism and phospholipid metabolism. A ceRNA network was constructed to reveal non-coding molecular regulatory mechanisms. Integrative analysis pinpointed core genes, proteins, metabolites, and potential biomarkers AGPAT2, HACD1, and ME1, which were significantly associated with GC prognosis.
HostingRepositoryiProX
AnnounceDate2025-06-06
AnnouncementXMLSubmission_2025-06-06_01:03:19.952.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLei Yang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-06-06 01:02:53ID requested
12025-06-06 01:03:20announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Gastric cancer, Peritoneal metastasis, Omental adipose tissue, Multi-omics, Biomarkers
Contact List
Chen Chai
contact affiliationThe People’s Hospital of Suzhou New District (SND)
contact emailchasechai@126.com
lab head
Lei Yang
contact affiliationThe First Hospital of Lanzhou University
contact emailyl41023@126.com
dataset submitter
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