PXD064705
PXD064705 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-Omics Analysis Reveals RNA Polymerase II Degradation as a Novel Mechanism of PF-3758309's Anti-Tumor Activity |
| Description | In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) via the cullin-RING ligase pathway. |
| HostingRepository | iProX |
| AnnounceDate | 2025-06-05 |
| AnnouncementXML | Submission_2025-06-05_23:46:07.833.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xinglong Jia |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | 6x(13)C labeled L-lysine; TMT6plex reporter fragment; ubiquitination signature dipeptidyl lysine |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-05 23:45:48 | ID requested | |
| ⏵ 1 | 2025-06-05 23:46:08 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PF-3758309, POLR2A/B/E, DDB2, MLN4924, Ubiquitin-proteasome system, Anti-tumor activity |
Contact List
| Minjia Tan | |
|---|---|
| contact affiliation | Shanghai institute of Materia Medica Chinese Academy of Sciences |
| contact email | Tanminjia@outlook.com |
| lab head | |
| Xinglong Jia | |
| contact affiliation | Shanghai institute of Materia Medica Chinese Academy of Sciences |
| contact email | jiaxlzzu@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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