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PXD064657
PXD064657 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exposure to Tebuconazole Drives Cross-Resistance to Clinical Triazoles in Aspergillus fumigatus |
| Description | The emergence of triazole resistance in Aspergillus fumigatus poses a significant threat to clinical antifungal therapy. This study investigated the impact of prolonged exposure to the agricultural triazole tebuconazole (TEB) on the susceptibility of A. fumigatus to clinical triazoles and explored associated resistance mechanisms. After 28 days of exposure, isolates exhibited substantial increases in minimum inhibitory concentrations (MICs): up to 128-fold for itraconazole, 64-fold for posaconazole, and 16-fold for voriconazole. Resistance persisted even after TEB removal. Ergosterol levels remained stable, while efflux pump inhibition led to MIC reduction, confirming their role in resistance. Proteomic analysis identified 193 upregulated and 88 downregulated proteins, with distinct profiles between treated and untreated groups. These findings demonstrate that agricultural triazoles can induce stable, multidrug-resistant phenotypes in A. fumigatus, emphasizing the need for integrated surveillance of antifungal resistance across environmental and clinical settings. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-09_17:35:54.362.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gonçalo Souza Filho |
| SpeciesList | scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: NEWT:746128; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | SYNAPT G2-Si |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-04 22:52:10 | ID requested | |
| ⏵ 1 | 2025-11-09 17:35:55 | announced |
Publication List
| 10.1021/acsomega.5c07812; |
| Meireles LM, Soares FS, de Souza Filho GA, Scherer R, . ACS Omega, 10(42):50407-50414(2025) [pubmed] |
Keyword List
| submitter keyword: enzyme inhibitor,Aspergillus, ergosterol, triazole, clinical azole, cross-resistance |
Contact List
| Gonçalo Apolinário de Souza Filho | |
|---|---|
| contact affiliation | Laboratório de Biotecnologia (Unidade de Biologia Integrativa, Setor de Genômica e Proteômica), Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Av. Alberto Lamego, 2000, Campos dos Goytacazes 28013-602, Rio de Janeiro, Brazil |
| contact email | goncalos@uenf.br |
| lab head | |
| Gonçalo Souza Filho | |
| contact affiliation | State University of Northern Rio de Janeiro (UENF) |
| contact email | goncalos@uenf.br |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD064657 |
| PRIDE project URI |
Repository Record List
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