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PXD064656
PXD064656 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pandemic Preparedness: An Easily Implemented LC-immuno-MRM-MS Winterplex Method for Respiratory Viral Screening |
| Description | Reliable large-scale testing for respiratory viruses, including Influenza viruses, coronaviruses (such as SARS-CoV-2), and respiratory syncytial virus (RSV) is essential for both endemic surveillance and pandemic response. While RT-qPCR remains the current gold standard, the COVID-19 pandemic highlighted the need for alternative, scalable diagnostic platforms. Although alternative approaches like liquid chromatography coupled with mass spectrometry (LC-MS) are ideally suited for viral multiplexing, they have yet to undergo clinical validation. Here, we present a quantitative immuno-MRM assay, called Winterplex, for the simultaneous detection of Influenza A, Influenza B, RSV, and SARS-CoV-2, each targeted via one proteotypic peptide per virus. The method was validated according to ISO standards for in vitro diagnostics and benchmarked against RT-qPCR. To strengthen future pandemic preparedness, urgent investment is needed to clinically translate and expand such multiplexed mass spectrometry-based diagnostics, enabling faster and more flexible responses to emerging viral threats. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-02-25 |
| AnnouncementXML | Submission_2026-02-25_11:14:45.013.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Bart Van Puyvelde |
| SpeciesList | scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049; scientific name: Influenza A virus; NCBI TaxID: 11320; scientific name: Respiratory syncytial virus; NCBI TaxID: 12814; scientific name: H5N1 subtype; NCBI TaxID: 102793; scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Influenza B virus; NCBI TaxID: 11520; scientific name: Gallus gallus; NCBI TaxID: 9031; |
| ModificationList | Deamidated; Oxidation; Label:13C(6)15N(2); Label:13C(6)15N(4); Label:15N(1); Label:15N(2); Label:15N(4) |
| Instrument | Xevo TQ-XS; ZenoTOF 7600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-04 22:49:47 | ID requested | |
| ⏵ 1 | 2026-02-25 11:14:45 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Influenza, RSV, SARS-CoV-2, immuno-MRM |
Contact List
| Maarten Dhaenens | |
|---|---|
| contact affiliation | ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University |
| contact email | maarten.dhaenens@ugent.be |
| lab head | |
| Bart Van Puyvelde | |
| contact affiliation | ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University |
| contact email | bart.vanpuyvelde@ugent.be |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
