PXD064647

PXD064647 is an original dataset announced via ProteomeXchange.

Title	Differences in protein acetylation in different parts of Crohn's gut
Description	Lysine acetylation is a rich post-translational modification in prokaryotes that regulates multiple immune response pathways, and its importance has been overlooked. Crohn's disease is a subtype of inflammatory bowel disease characterized by chronic inflammation involving the entire gastrointestinal tract. CD-induced intestinal damage and subsequent disability is a growing global health problem. However, the pathophysiology of this disease is not fully understood, and the level of protein acetylation in Crohn's gut tissue is not well understood.To determine the level of protein acetylation in different intestinal sites of CD and changes in intestinal immune response after colonic protein acetylation. Colon, cecum, and rectal tissues of Crohn's disease and healthy control mice were detected by acetylation proteomics. ResultsThe analysis determined that there were up to 624 acetylated proteins and 1809 acetylation sites in intestinal tissue, which were different in the disease and control groups, and the acetylated proteins were enriched in immunomodulatory signaling pathways such as NF-κB, MAPK, and Wnt.
HostingRepository	PRIDE
AnnounceDate	2026-04-10
AnnouncementXML	Submission_2026-04-10_09:10:27.517.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tao Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-04 18:22:47	ID requested
⏵ 1	2026-04-10 09:10:28	announced

Dataset with its publication pending

submitter keyword: Crohn, signaling pathways, immune response, Protein acetylation

Yajing Guo
contact affiliation	Henan University of Chinese Medicine
contact email	guoyajing0817@163.com
lab head
Tao Li
contact affiliation	17765116266
contact email	litao@mass-hub.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064647
     1. Label: PRIDE project
     2. Name: Differences in protein acetylation in different parts of Crohn's gut