PXD064637

PXD064637 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DIA-Based Quantitative Proteomic Analysis of Early and Late Endosomes in A549 Cells Following Amphotericin B Pretreatment and Influenza A Virus Infection
Description	Amphotericin B (AmB) is a polyene macrolide antifungal agent that binds to ergosterol, disrupting fungal membranes through lipid interactions. However, its effects on host cell protein composition remain unclear. In this study, A549 cells were pretreated with AmB prior to infection with the influenza A virus, and early and late endosomal fractions were isolated. DIA-based quantitative proteomics revealed that AmB alters the protein composition of endosomes during infection, suggesting that it modulates endosomal protein dynamics in virus-infected cells.
HostingRepository	PRIDE
AnnounceDate	2026-02-02
AnnouncementXML	Submission_2026-02-02_07:46:48.974.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Di He
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-04 10:26:15	ID requested
⏵ 1	2026-02-02 07:46:49	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Amphotericin B
Influenza A virus
Endosome
DIA proteomics

submitter keyword: Amphotericin B

Influenza A virus

Endosome

DIA proteomics

Contact List

Bin Cao
contact affiliation	China-Japan Friendship Hospital, China
contact email	caobin_ben@163.com
lab head
Di He
contact affiliation	China-Japan Friendship Hospital
contact email	hd980122@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD064637
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD064637

PRIDE project URI

Repository Record List

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