PXD064634

PXD064634 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PBMC proteomics in paediatric obesity
Description	We isolated cell lysate proteins from PBMCs obtained from 71 children and adolescents (age 5-18) with normal weight, overweight or obesity. Body composition was measured using bioelectrical impedance analysis. Nano-electrospray liquid chromatography-tandem mass spectrometry was used to measure protein abundances. Controlling for patient sex, we investigated changes in abundance depending on leukocyte counts and on percentage body fat (PBF). We show protein expression in PBMCs is altered in children with increased PBF, especially in mitochondrial proteins. These obesity-associated changes in are better explained by PBF than by purely height and weight-based metrics, supporting the utility of bioelectrical impedance analysis in obesity research.
HostingRepository	PRIDE
AnnounceDate	2025-07-06
AnnouncementXML	Submission_2025-07-05_22:43:20.517.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maya Petek
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-04 08:18:41	ID requested
⏵ 1	2025-07-05 22:43:20	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: proteomics, bioelectrical impedance analysis, body composition,paediatric obesity, peripheral blood mononuclear cells

submitter keyword: proteomics, bioelectrical impedance analysis, body composition,paediatric obesity, peripheral blood mononuclear cells

Contact List

Uroš Potočnik
contact affiliation	Faculty of Medicine, University of Maribor, Slovenia Faculty of Chemistry and Chemical Engineering, University of Maribor, Slovenia
contact email	uros.potocnik@um.si
lab head
Maya Petek
contact affiliation	Faculty of Medicine, University of Maribor
contact email	maya.petek@um.si
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD064634
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD064634

PRIDE project URI

Repository Record List

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