PXD064580

PXD064580 is an original dataset announced via ProteomeXchange.

Title	Cutaneous Lupus Erythematosus: proteomics salivary profiling
Description	Background: Cutaneous lupus erythematosus (CLE) is a complex autoimmune condition with limited data on its molecular underpinnings. Saliva, as plasma filtrate fluid may be a promising tool for biomarkers discovery, since it is an easily accessible biofluid. This study aimed to characterize the salivary proteomic profile of CLE patients compared to healthy controls, to identify potential disease-specific biomarkers. Methods: Ten females diagnosed with CLE and twelve controls without autoimmune conditions were included in the study. Saliva samples were collected under controlled conditions and analyzed using mass spectrometry and chromatography. Proteomic analysis was performed with the nanoElute nanoflow system coupled to a timsTof-Pro mass spectrometer. Results: Among the 104 proteins identified, six showed statistically significant differences between groups. PEBP1 (RKIP), ARG1, TALDO, and CTSZ were upregulated in CLE, while TFF3 and PRDX4 were absent. These proteins are involved in immune regulation, metabolic processes, redox balance, and inflammation. RKIP and ARG1 showed high discriminatory power (AUROC = 1.0), suggesting their potential as CLE biomarkers. Conclusion: This study establishes a distinct salivary proteomic signature in CLE, highlighting a panel of proteins with diagnostic potential. The use of saliva and proteomic techniques offers a powerful approach to unravel CLE pathophysiology and supports future research on non-invasive biomarkers for disease monitoring and personalized care.
HostingRepository	PRIDE
AnnounceDate	2025-12-22
AnnouncementXML	Submission_2025-12-21_17:07:07.961.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giovanna Florezi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-03 16:18:31	ID requested
⏵ 1	2025-12-21 17:07:09	announced

Florezi GP, Barone FP, Labate MTV, Labate CA, Nico MMS, Louren, ç, o SV, Salivary proteomics profiling in cutaneous lupus erythematosus. Lupus, 35(2):120-128(2026) [pubmed]

10.1177/09612033251407232;

submitter keyword: cutaneous lupus erythematosus, proteomics, saliva

Carlos Alberto Labate
contact affiliation	Escola Superior de Agricultura Luiz de Queiroz da Universidade de São Paulo
contact email	calabate@usp.br
lab head
Giovanna Florezi
contact affiliation	Faculdade de Odontologia da Universidade de São Paulo
contact email	giovanna.florezi@usp.br
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064580
     1. Label: PRIDE project
     2. Name: Cutaneous Lupus Erythematosus: proteomics salivary profiling