PXD064578

PXD064578 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The HDAC1/DNTTIP1/Flag-tagged MIDEAS (Tyr654Ser) complex was expressed by transient transfection in HEK293F cells. The complex was purified using anti-flag resin and gel filtration. You from here
Description	Analysis of the phosphorylation state of a mis-sense variant in MIDEAS (Tyr654Ser). The substitution from YTP to STP generates a CDK kinase site that is phosphorylated in a human cell line.
HostingRepository	PRIDE
AnnounceDate	2026-08-18
AnnouncementXML	Submission_2026-08-18_06:45:45.885.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD064578
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Rebekah Jukes-Jones
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-03 15:40:21	ID requested
⏵ 1	2026-08-18 06:45:46	announced

Publication List

10.1038/s41467-025-65472-x;
10.6019/PXD064578;
Fairall L, Sirvydis K, Turnbull RE, Knottnerus SJ, Gonchar O, Muskett FW, Jukes-Jones R, van Brussel L, van de Geer E, van Gassen K, Badenhorst P, Johnson D, Terhal PA, van Hasselt PM, van Jaarsveld RH, Schwabe JW, A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome. Nat Commun, 16(1):10472(2025) [pubmed]

10.1038/s41467-025-65472-x;

10.6019/PXD064578;

Fairall L, Sirvydis K, Turnbull RE, Knottnerus SJ, Gonchar O, Muskett FW, Jukes-Jones R, van Brussel L, van de Geer E, van Gassen K, Badenhorst P, Johnson D, Terhal PA, van Hasselt PM, van Jaarsveld RH, Schwabe JW, A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome. Nat Commun, 16(1):10472(2025) [pubmed]

Keyword List

submitter keyword: Human, HDAC1, TDIF, Histone deacetylase, ELmSAN1, DNTTIP1, MIDEAS

submitter keyword: Human, HDAC1, TDIF, Histone deacetylase, ELmSAN1, DNTTIP1, MIDEAS

Contact List

John Schwabe
contact affiliation	Leicester Institute of Structural Biology, Molecular and Cell Biology, Univeristy of Leicester United Kingdom
contact email	john.schwabe@le.ac.uk
lab head
Rebekah Jukes-Jones
contact affiliation	University of Leicester
contact email	rjj18@leicester.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD064578
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD064578

PRIDE project URI

Repository Record List

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