PXD064521 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Klebsiella pneumoniae LPS drives stromal-mediated repression of p53 and colorectal cancer chemoresistance |
| Description | Evidence has emerged that the bacterial microbiota is a key modulator of colorectal cancer (CRC) response to therapy, but the molecular mechanisms of this interplay are poorly understood. Here, we investigate the effects of microbiota-driven signalling on the tumour suppressor p53 and its impact on chemotherapy. We uncover a mechanism by which lipopolysaccharide (LPS) from Klebsiella pneumoniae and other Enterobacteria impairs p53 activity and promotes chemoresistance via paracrine signalling from the tumour microenvironment. We observed that conditioned media from LPS-stimulated macrophages or fibroblasts suppressed p53 accumulation and attenuated the response to chemotherapeutic agents. Our data revealed selective inhibition of a subset of p53 targets by inflammation. This same subset negatively correlated with inflammatory signature and immune infiltration in patients and was associated with improved survival following chemotherapy. Our findings reveal a microbiota-driven mechanism of p53 suppression via the microenvironment that contributes to chemoresistance and highlight the impact of bacteria on tumour cell fate and therapeutic efficacy in CRC. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-26_17:28:54.855.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Akos Vegvari |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-02 10:11:54 | ID requested | |
| ⏵ 1 | 2026-04-26 17:28:55 | announced | |
Publication List
| 10.1038/s41419-026-08756-4; |
| Fragkoulis K, Ł, asut-Szyszka B, V, é, gv, á, ri Á, Ayona D, Saei AA, Aschtgen MS, Peuget S, Klebsiella pneumoniae LPS drives stromal-mediated repression of p53 and colorectal cancer chemoresistance. Cell Death Dis, 17(1):(2026) [pubmed] |
Keyword List
| submitter keyword: LPS, colorectal cancer cells, 5-FU,Klebsiella pneumoniae |
Contact List
| Akos Vegvari |
|---|
| contact affiliation | Karolinska Institutet, Stockholm, Sweden |
| contact email | akos.vegvari@ki.se |
| lab head | |
| Akos Vegvari |
|---|
| contact affiliation | Karolinska Institutet |
| contact email | akos.vegvari@ki.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064521
- Label: PRIDE project
- Name: Klebsiella pneumoniae LPS drives stromal-mediated repression of p53 and colorectal cancer chemoresistance
