PXD064470 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | GPLD1 Attenuates Heart Failure via Dual Membrane Localization to inhibit uPAR |
| Description | GPLD1 levels were elevated in HF patients and murine models. Cardiac-specific GPLD1 depletion exacerbated cardiac dysfunction and hypertrophy, while its overexpression ameliorated these effects, dependent on enzymatic activity. uPAR was identified as a potential binding target for GPLD1, and viral-mediated uPAR transduction completely abolished the protective effects of GPLD1 following TAC surgery. Mechanistically, GPLD1 was anchored to the plasma membrane and outer mitochondrial membrane via PI(4,5)P2 to cleave the GPI anchor of uPAR, thereby maintaining calcium homeostasis and mitochondrial function, and ultimately ameliorating cardiac dysfunction. Conversely, excess uPAR led to a decrease in PI(4,5)P2 levels, preventing the localization of GPLD1 to these membranes and causing it to disperse in the cytoplasm. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_16:19:13.746.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huimin Liang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-31 00:41:14 | ID requested | |
| ⏵ 1 | 2026-09-06 16:19:14 | announced | |
Publication List
| 10.1161/circresaha.124.325623; |
| Yu W, Guo Z, Liang H, Ma D, Lin C, Li Z, Yu J, Ataran A, Javaheri A, Liu Z, Sun D, Liu P, Lu J, GPLD1 Attenuates Heart Failure via Dual-Membrane Localization to Inhibit uPAR. Circ Res, 137(5):e124-e143(2025) [pubmed] |
Keyword List
| submitter keyword: Heart Failure |
| uPAR |
| PI(4,5)P2 |
| calcium homeostasis.,GPLD1 |
Contact List
| lu jing |
|---|
| contact affiliation | Laboratory of Pharmacology & Toxicology,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou, China |
| contact email | lujing28@mail.sysu.edu.cn |
| lab head | |
| Huimin Liang |
|---|
| contact affiliation | Sun Yat-sen University |
| contact email | lianghm37@mail2.sysu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD064470 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064470
- Label: PRIDE project
- Name: GPLD1 Attenuates Heart Failure via Dual Membrane Localization to inhibit uPAR
