PXD064423

PXD064423 is an original dataset announced via ProteomeXchange.

Title	An early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.
Description	We identified changes in the protein arginine methylome during the initial 30 min of TCR engagement and discovered a novel arginine methylation of a Ca2+ -activated potassium transporter, KCa3.1, which regulates Ca2+ -mediated NFAT1 signaling to ensure optimal activation.
HostingRepository	PRIDE
AnnounceDate	2025-05-29
AnnouncementXML	Submission_2025-05-29_11:57:57.477.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Suresh Poudel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monomethylated residue; dimethylated L-arginine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-29 11:45:15	ID requested
⏵ 1	2025-05-29 11:57:57	announced

Dataset with its publication pending

submitter keyword: Arginine,Protein, Methylome

Douglas R. Green
contact affiliation	St. Jude Children's Research Hospital
contact email	douglas.green@stjude.org
lab head
Suresh Poudel
contact affiliation	St. Jude Childrens's Research Hospital
contact email	sureshbt42@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD064423

PRIDE project URI

• PRIDE
  1. PXD064423
     1. Label: PRIDE project
     2. Name: An early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.