PXD064375

PXD064375 is an original dataset announced via ProteomeXchange.

Title	Utilizing a bioartificial 3D bronchial epithelial airway model to study lunar hay fever on Earth
Description	This study underscores the urgent need to understand how lunar regolith dust affects human health, an issue critical for sustaining long-term human presence on the Moon. Past Apollo missions, revealed that lunar dust exposure can trigger allergy-like symptoms, suggesting a biological reactivity that is still poorly understood. Using a 3D human airway model that closely mimics real bronchial tissue, researchers found that lunar regolith simulant (JSC-1) causes unique and early physiological changes that differ significantly from responses to Earth-based dust (PM10). The distinct effects of lunar regolith on mucociliary clearance, barrier integrity, and airway remodeling suggest that cellular and molecular pathways are being activated or suppressed in ways not seen with terrestrial particles. Proteomics can uncover which specific proteins are altered during exposure, providing insight into the mechanisms of toxicity, stress response, and long-term adaptation or damage. Moreover, the data reinforces that terrestrial dust studies are not directly translatable to the lunar context. Therefore, proteomic profiling specific to lunar dust exposure is not just beneficial, it's necessary to develop targeted medical countermeasures, design safer habitats, and support the health of future lunar explorers.
HostingRepository	PRIDE
AnnounceDate	2026-04-10
AnnouncementXML	Submission_2026-04-10_09:07:29.789.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patrick Hellwig
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-28 07:04:08	ID requested
⏵ 1	2026-04-10 09:07:30	announced

Dataset with its publication pending

submitter keyword: Lunar regolith dust 3D human airway model Bronchial epithelium Lunar regolith simulant Proteomics

Marcus Krüger
contact affiliation	Department of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany
contact email	marcus.krueger@med.ovgu.de
lab head
Patrick Hellwig
contact affiliation	Otto-von-Guericke-University Universitätsplatz 2 39106 Magdeburg Germany
contact email	hellwig@mpi-magdeburg.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD064375

PRIDE project URI

• PRIDE
  1. PXD064375
     1. Label: PRIDE project
     2. Name: Utilizing a bioartificial 3D bronchial epithelial airway model to study lunar hay fever on Earth