PXD064369 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Retromer-Driven Membrane Trafficking of MOSPD2 Enables LEAP2-Induced Chemotaxis via VPS35 Interaction in Boleophthalmus pectinirostris |
| Description | Our previous study demonstrated that Boleophthalmus pectinirostris MOSPD2 (BpMOSPD2) is the receptor of BpLEAP2. In subsequent experiments, we observed that BpMOSPD2 undergoes membrane translocation in the presence of BpLEAP2. However, BpMOSPD2 contains only five amino acids in its intracellular region, which greatly limits its intracellular activity. Therefore, we employed a combined immunoprecipitation–mass spectrometry (IP-MS) approach to identify potential intracellular proteins associated with BpMOSPD2, aiming to better explain the membrane translocation process of BpMOSPD2 in the presence of BpLEAP2. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-01-11_16:06:51.541.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | tingfang Zhu |
| SpeciesList | scientific name: Boleophthalmus pectinirostris; NCBI TaxID: NEWT:150288; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-28 02:57:35 | ID requested | |
| ⏵ 1 | 2026-01-11 16:06:52 | announced | |
Publication List
| 10.24272/j.issn.2095-8137.2025.307; |
| Zhu TF, Zhao ZY, Fei CJ, Shen SC, Shao JZ, Nie L, Chen J, LEAP2 triggers retromer-mediated membrane trafficking of MOSPD2 to promote chemotaxis in teleost monocytes/macrophages. Zool Res, 46(5):1153-1164(2025) [pubmed] |
Keyword List
| submitter keyword: BpMOSPD2,BpVPS35, Retromer complex, Membrane trafficking |
Contact List
| Tingfang zhu |
|---|
| contact affiliation | Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang 315211, China |
| contact email | 17855828736@163.com |
| lab head | |
| tingfang Zhu |
|---|
| contact affiliation | Ningbo university |
| contact email | 17855828736@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD064369 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064369
- Label: PRIDE project
- Name: Retromer-Driven Membrane Trafficking of MOSPD2 Enables LEAP2-Induced Chemotaxis via VPS35 Interaction in Boleophthalmus pectinirostris
