PXD064353

PXD064353 is an original dataset announced via ProteomeXchange.

Title	Histamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans
Description	Histamine receptor antagonists, commonly used to treat allergies, block histamine signalling and have been shown to impair acute and chronic adaptations to high-intensity and endurance-type exercise. Since it remains unclear whether this is a universal mechanism of muscle adaptation, this study investigated the effect of histamine receptor blockade on resistance training adaptations. Eighteen men performed 10 weeks of resistance training with either a placebo (n=9) or H1 receptor antihistamine (n=9, 180mg fexofenadine) intake before each training session. Outcomes assessed before and after the intervention included maximal strength (1RM), muscle volume (MRI), fat mass (skinfolds), fat free mass, whole-body glucose tolerance (OGTT), vascular function, dietary intake (self-reported food diaries) and muscle proteome remodelling. Both the placebo and antihistamine groups showed similar increases in muscle volume (+7% and +8%) and maximal strength (+14% and +20%) and reductions in diastolic blood pressure (-6 and -5 mmHg), total glucose level (-24% and -10%) and total insulin level (-10% and -9%) during the OGTT. Unexpectedly, the blockade group gained fat mass (+0.6 kg), while the placebo group did not (-0.3 kg), which could be related to increased dietary carbohydrate intake in the blockade, but not the placebo group (+29% vs -7%). In conclusion, histamine blockade did not impair resistance training-induced adaptations, suggesting that intercellular H1-histaminergic crosstalk is not a universal mechanism across training modalities. However, antihistamine intake led to increased habitual food intake and fat mass following 10 weeks of resistance training, possibly linked to a role of histamine in appetite regulation.
HostingRepository	PRIDE
AnnounceDate	2026-03-04
AnnouncementXML	Submission_2026-03-04_12:49:41.445.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roger Moreno Justicia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF SCP

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-28 00:22:58	ID requested
⏵ 1	2026-03-04 12:49:42	announced

10.1113/jp289240;

Van de Loock A, Vandecauter J, Ullrich M, Lievens E, Schro, é H, Moreno-Justicia R, Weyns A, Van Thienen R, Calders P, Deshmukh AS, Van der Stede T, Derave W, weeks of resistance training in humans. J Physiol, ():(2025) [pubmed]

submitter keyword: fat mass,resistance training, food intake, muscle adaptations, H1 antihistamines, histamine

Atul Deshmukh
contact affiliation	Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
contact email	atul.deshmukh@sund.ku.dk
lab head
Roger Moreno Justicia
contact affiliation	Novo Nordisk Foundation Center for Basic Metabolic Research
contact email	roger.moreno.justicia@sund.ku.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064353
     1. Label: PRIDE project
     2. Name: Histamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans