PXD064318

PXD064318 is an original dataset announced via ProteomeXchange.

Title	Research on the mechanism by which cancer-associated fibroblasts (CAFs) promote EGFR-TKI resistance in non-small cell lung cancer (NSCLC) via secretory proteins
Description	Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major clinical challenge in the targeted therapy of non-small cell lung cancer (NSCLC), yet its underlying mechanisms are poorly understood. The tumor microenvironment (TME), which provides a supportive niche for cancer cell survival and progression, plays a pivotal role in NSCLC drug resistance. Our preliminary studies revealed that activated cancer-associated fibroblasts (CAFs) in the TME induce EGFR-TKI resistance in lung cancer cells by secreting neuregulin-1 (NRG1). Further investigations identified STAT3 as a key regulator of CAF activation and secretory function. We thus hypothesize that inhibiting STAT3 activation may block CAF-mediated secretion, thereby reversing EGFR-TKI resistance in lung cancer.
HostingRepository	iProX
AnnounceDate	2025-05-26
AnnouncementXML	Submission_2025-05-26_19:54:52.093.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhe Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-26 19:54:38	ID requested
⏵ 1	2025-05-26 19:54:52	announced

Dataset with its publication pending

submitter keyword: CAF, EGFR-TKI

Zhe Liu
contact affiliation	Bengbu Medical University
contact email	117915493@qq.com
lab head
Zhe Liu
contact affiliation	Bengbu Medical University
contact email	117915493@qq.com
dataset submitter

iProX dataset URI