PXD064318
PXD064318 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Research on the mechanism by which cancer-associated fibroblasts (CAFs) promote EGFR-TKI resistance in non-small cell lung cancer (NSCLC) via secretory proteins |
| Description | Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major clinical challenge in the targeted therapy of non-small cell lung cancer (NSCLC), yet its underlying mechanisms are poorly understood. The tumor microenvironment (TME), which provides a supportive niche for cancer cell survival and progression, plays a pivotal role in NSCLC drug resistance. Our preliminary studies revealed that activated cancer-associated fibroblasts (CAFs) in the TME induce EGFR-TKI resistance in lung cancer cells by secreting neuregulin-1 (NRG1). Further investigations identified STAT3 as a key regulator of CAF activation and secretory function. We thus hypothesize that inhibiting STAT3 activation may block CAF-mediated secretion, thereby reversing EGFR-TKI resistance in lung cancer. |
| HostingRepository | iProX |
| AnnounceDate | 2025-05-26 |
| AnnouncementXML | Submission_2025-08-05_21:57:44.868.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhe Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-26 19:54:38 | ID requested | |
| 1 | 2025-05-26 19:54:52 | announced | |
| ⏵ 2 | 2025-08-05 21:57:45 | announced | 2025-08-06: Add info. |
Publication List
| Fan X, Wu S, Wu H, Huang Y, Tong X, Yu M, Liu Z, STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer. Front Pharmacol, 16():1546491(2025) [pubmed] |
Keyword List
| submitter keyword: CAF, EGFR-TKI |
Contact List
| Zhe Liu | |
|---|---|
| contact affiliation | Bengbu Medical University |
| contact email | 117915493@qq.com |
| lab head | |
| Zhe Liu | |
| contact affiliation | Bengbu Medical University |
| contact email | 117915493@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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