PXD064264

PXD064264 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Full-Thickness Rotator Cuff Tears: Potential Role of Tetranectin in Synovial Fluid
Description	Rotator cuff tears are one of the most common shoulder disorders and can lead to pain, weakness, and limited mobility. Although the clinical condition has been widely studied, its molecular mechanisms are still not fully understood. In this study, we analyzed the proteomic profile of synovial fluid in patients with full-thickness rotator cuff tears and compared the results to those from a control group. Proteomic analysis was performed on synovial fluid samples from seven patients with full-thickness tears and three patients with partial-thickness tears, who served as the control group. Label-free quantification using the MaxQuant platform identified 284 proteins at 1% FDR. Among them, CLEC3B (tetranectin) showed the most significant difference, with a fold change of approximately 40 and a p-value of 2.6 × 10⁻³. Gene ontology enrichment analysis revealed biological processes related to extracellular matrix remodeling, fibrinolysis, and inflammation. Given its known roles in extracellular matrix remodeling, tetranectin identified as a candidate for full-thickness rotator cuff tears, providing insight into pathological processes such as tendon degeneration and fatty infiltration.
HostingRepository	PRIDE
AnnounceDate	2026-06-08
AnnouncementXML	Submission_2026-06-07_17:20:25.033.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chae Eun Moon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-24 09:30:34	ID requested
⏵ 1	2026-06-07 17:20:25	announced

Moon CE, Do WS, Kang YM, Ji YW, Lim JR, Tetranectin is significantly elevated in the synovial fluid of patients with full-thickness rotator cuff tears. Sci Rep, 16(1):(2026) [pubmed]

10.1038/s41598-026-43241-0;

submitter keyword: Full-Thickness Rotator Cuff Tears, Synovial Fluid, Proteomics, Tetranectin

JOONRYUL LIM
contact affiliation	Department of Orthopaedic Surgery, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea
contact email	YALLEEYALLEE@yuhs.ac
lab head
Chae Eun Moon
contact affiliation	Yonsei University College of Medicine
contact email	cemoon@yuhs.ac
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064264
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Full-Thickness Rotator Cuff Tears: Potential Role of Tetranectin in Synovial Fluid