PXD064237

PXD064237 is an original dataset announced via ProteomeXchange.

Title	Protein identification of recombinant SLFN11 and SLFN14
Description	The Schlafen (SLFN) family of nucleic acid binding proteins play an important role in gene regulation. In response to environmental stress, many SLFN members are activated for RNA cleavage and translational regulation. To characterize the RNA cleavage activity of this protein family, we produced recombinant human SLFN11 and SLFN14 protein. We utilized mass spectrometry for protein identification to confirm the identity of our recombinant SLFN protein samples.
HostingRepository	PRIDE
AnnounceDate	2025-07-08
AnnouncementXML	Submission_2025-07-08_08:34:45.086.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antrix Jain
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-23 06:12:08	ID requested
⏵ 1	2025-07-08 08:34:45	announced

10.1038/s41467-025-61091-8;

Van Riper J, Martinez-Claros AO, Wang L, Schneiderman HE, Maheshwari S, Pillon MC, CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage. Nat Commun, 16(1):5848(2025) [pubmed]

submitter keyword: Schlafen, SLFN11, SLFN14

Monica C. Pillon
contact affiliation	Department of Structural Biology Jacobs School of Medicine and Biomedical Sciences University at Buffalo, Buffalo, NY
contact email	mpillon@buffalo.edu
lab head
Antrix Jain
contact affiliation	Baylor College of Medicine
contact email	antrixj@bcm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD064237

PRIDE project URI

• PRIDE
  1. PXD064237
     1. Label: PRIDE project
     2. Name: Protein identification of recombinant SLFN11 and SLFN14