PXD064184

PXD064184 is an original dataset announced via ProteomeXchange.

Title	Proteomics and phosphoproteomics of medicinal cannabis plant extract (NTI164) treatment of paediatric acute-onset neuropsychiatric syndrome
Description	Paediatric acute-onset neuropsychiatric Syndrome (PANS) is a syndrome of infection-provoked abrupt-onset obsessive-compulsive disorder (OCD) or eating restriction. This open-label trial investigated the safety and efficacy of NTI164, a cannabis-derived medicinal formulation rich in cannabinoids (minimal tetrahydrocannabinol), at 20 mg/kg/day for 12 weeks in 14 children with chronic-relapsing PANS (mean 12.1 years, females 29%). Proteomics, phosphoproteomics, and other omics approaches revealed baseline dysregulation of multiple signalling pathways in PANS versus controls that were significantly modified following NTI164 treatment.
HostingRepository	PRIDE
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-03-16_06:08:26.523.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD064184
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mark Graham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-22 01:55:01	ID requested
⏵ 1	2026-03-16 06:08:27	announced

10.1016/j.neurot.2025.e00828;

Keating BA, Han VX, Nishida H, Aryamanesh N, Marshall LL, Gloss BS, Lau X, Dissanayake R, Dervish S, Graham ME, Mohammad SS, Kanhangad M, Fahey MC, Patel S, Dale RC, Medicinal cannabis plant extract (NTI164) modifies epigenetic, ribosomal, and immune pathways in paediatric acute-onset neuropsychiatric syndrome. Neurotherapeutics, 23(1):e00828(2026) [pubmed]

10.6019/PXD064184;

submitter keyword: epigenetics, multi-omics, QE Plus, immune, TMT, ribosome,cannabis, PANS, translation

Russell Dale
contact affiliation	Kids Neuroscience Centre, Kids Research, Sydney Children Hospital Network
contact email	russell.dale@health.nsw.gov.au
lab head
Mark Graham
contact affiliation	Children's Medical Research Institute
contact email	mgraham@cmri.org.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD064184

PRIDE project URI

• PRIDE
  1. PXD064184
     1. Label: PRIDE project
     2. Name: Proteomics and phosphoproteomics of medicinal cannabis plant extract (NTI164) treatment of paediatric acute-onset neuropsychiatric syndrome