PXD064183
PXD064183 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Urinary proteome and metabolome uncover tumor microenvironment and cellular metabolism changes of renal clear cell carcinoma |
Description | We applied LC-MS to profile the urine proteome and metabolome of 314 ccRCC, 341 healthy control and 49 kidney benign disease enrolled from three cohorts to a great depth. Functionally, we revealed significant changes of extracellular matrix (ECM) organization, complement and coagulation cascades, amino acid metabolism and fatty acid metabolism in ccRCC. Further cell origin annotation of cancer associated proteins revealed the potential role of myofibroblast cell, pericyte cell, vascular associated smooth muscle cell, and endothelial cell during ECM organization. Protein-protein correlation analysis suggested potential cell-cell communications in tumor TME, especially for tumor and myofibroblast cell. Finally, we discovered four potential urinary biomarkers, FGB,CILP, ITIH1, and GUCA2B, and established a model for ccRCC diagnosis with the AUC value of 0.84 in an external cohort. The model also showed discriminatory ability for ccRCC and benign with the AUC value of 0.75. Present study provided urinary molecular changes, which could reflect TME disorder and cellular metabolism reprogramming |
HostingRepository | iProX |
AnnounceDate | 2025-05-22 |
AnnouncementXML | Submission_2025-05-22_01:16:26.645.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xiaoyan Liu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion; Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-05-22 01:15:41 | ID requested | |
⏵ 1 | 2025-05-22 01:16:27 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Urine,proteomics,metabolomics, renal clear cell carcinoma |
Contact List
Wei Sun | |
---|---|
contact affiliation | Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College |
contact email | sunwei1018@sina.com |
lab head | |
Xiaoyan Liu | |
contact affiliation | Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College |
contact email | xiaoyanliu.good@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |