⮝ Full datasets listing
PXD064162
PXD064162 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrated multi-omic analysis reveals novel subtype-specific regulatory interactions in pediatric B-cell acute lymphoblastic leukemia |
| Description | In this study, we performed proteomic and phosphoproteomic profiling of B-cell acute lymphoblastic leukemia (B-ALL) samples collected at diagnosis and remission from pediatric leukemia patients with one of two subtypes of B-ALL: BCR::ABL1-like (Ph-like) and ETV6::RUNX1. We analyzed each dataset, as well as existing RNAseq data at diagnosis, to identify subtype-specific features, including increased calcium-dependent signaling in Ph-like samples. We then performed an integrated analysis of all three datasets, which enabled us to identify multiple layers of regulation, including subtype-specific phosphorylation of known cancer-associated proteins. Taken together, these data add to our understanding of the molecular profile of Ph-like and ETV6::RUNX1 B-ALL, demonstrating the utility of multi-omic comparison in pediatric leukemia subtype characterization. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-03-02 |
| AnnouncementXML | Submission_2026-03-02_10:26:28.783.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Michaella Rekowski |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Carbamidomethyl |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-21 11:48:47 | ID requested | |
| ⏵ 1 | 2026-03-02 10:26:29 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: B-cell acute lymphoblastic leukemia, multiomics, phosphoproteomics, DatasetType:Proteomics |
Contact List
| Midhat S Farooqi | |
|---|---|
| contact affiliation | Children's Mercy Hospital |
| contact email | msfarooqi@cmh.edu |
| lab head | |
| Michaella Rekowski | |
| contact affiliation | University of Kansas Medical Center |
| contact email | mrekowski@kumc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097955/ |
