PXD064153

PXD064153 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	proteomics analysis of SDe2 cleavage in lysate fractions from Expi293 cells
Description	SDE2, a highly conserved and essential gene required for genome maintenance, coordinates essential processes ranging from pre-mRNA splicing and ribosome biogenesis to DNA repair and replication stress response. It is expressed as a full-length precursor (SDE2FL,) bearing an N-terminal ULD, which is proteolytically cleaved to generate two protein fragments, SDE2UBL and the larger C-terminal domain (SDE2CT). In this study we report the identification of the protease responsible for SDE2 processing, resolving a previously uncharacterized mechanism of post-translational regulation.
HostingRepository	PRIDE
AnnounceDate	2026-06-24
AnnouncementXML	Submission_2026-06-24_06:58:40.719.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frederic Lamoliatte
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-21 08:26:11	ID requested
⏵ 1	2026-06-24 06:58:41	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: ubiquitin-like fusion proteins,SDE2, proteolysis

submitter keyword: ubiquitin-like fusion proteins,SDE2, proteolysis

Contact List

Chiara Maniaci
contact affiliation	Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
contact email	CManiaci001@dundee.ac.uk
lab head
Frederic Lamoliatte
contact affiliation	University of Dundee
contact email	flamoliatte001@dundee.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD064153
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD064153

PRIDE project URI

Repository Record List

[ + ]