PXD064150

PXD064150 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling of Uveal Melanoma Cells Treated with DHA and CCCP
Description	Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with limited treatment options and poor clinical outcomes. Dihydroartemisinin (DHA), have shown anti-tumor activity in UM, though typically at high concentrations. This study investigates the synergistic anti-tumor effects of combining DHA with a mitochondrial uncoupler CCCP. We treated UM cells with DHA and/or CCCP, and then proteomic profiling was performed to elucidate molecular mechanisms underlying the enhanced efficacy of the combination treatment. Our results indicate that co-treatment induces endoplasmic reticulum stress and activates autophagic cell death pathways, highlighting a potential combinatorial therapeutic strategy for UM.
HostingRepository	PRIDE
AnnounceDate	2025-06-10
AnnouncementXML	Submission_2025-06-10_07:16:10.826.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Minyue Xie
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-21 07:25:58	ID requested
⏵ 1	2025-06-10 07:16:11	announced

Dataset with its publication pending

submitter keyword: Human, uveal melanoma, DHA, CCCP

Xianqun Fan
contact affiliation	Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
contact email	fanxq@sjtu.edu.cn
lab head
Minyue Xie
contact affiliation	Beijing Tongren Hospital
contact email	2238445761@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD064150

PRIDE project URI

• PRIDE
  1. PXD064150
     1. Label: PRIDE project
     2. Name: Proteomic Profiling of Uveal Melanoma Cells Treated with DHA and CCCP