PXD064138

PXD064138 is an original dataset announced via ProteomeXchange.

Title	Salivary Proteomics as a Potential Tool for Early Lung Cancer Detection: Insights from the East Khasi Hills, Meghalaya, India
Description	Lung cancer remains a significant global health challenge, particularly in marginalized areas where access to early diagnostic tools is limited. The present study examined the potential of salivary proteomics as a non-invasive, cost-effective method for early lung cancer detection. Saliva samples were collected from 15 lung cancer patients and 15 matched healthy controls from the East Khasi Hills district of Meghalaya, India. Using liquid chromatography–tandem mass spectrometry (LC-MS/MS), a total of 2,784 proteins were identified, with 290 showing statistically significant differences in expression between the cancer and control groups. Among these, seven proteins (TUBB3, PTBP3, ESYT1, Rab27B, RUVBL1, Pyruvate Carboxylase, and CDK5RAP2) were uniquely expressed in cancer samples, suggesting their potential as specific biomarkers. Several proteins, including Kallikrein-7 (KLK7), Bleomycin Hydrolase (BLMH), HMGN5, GLUD1, and GLUL, were significantly upregulated in the saliva of lung cancer patients, indicating their role in tumor growth, chemoresistance and altered metabolism. Statistical analyses such as heatmap clustering, PCA, and volcano plots, confirmed distinct proteomic signatures between the cancer and control groups. These findings support the potential of salivary proteomics as a cost-effective and non-invasive tool for early lung cancer detection.
HostingRepository	PRIDE
AnnounceDate	2025-11-03
AnnouncementXML	Submission_2025-11-03_02:39:36.453.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roumi Deb
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-21 03:26:39	ID requested
⏵ 1	2025-11-03 02:39:36	announced

Dataset with its publication pending

submitter keyword: Saliva, Non-Invasive Detection, Khasi hills, Early diagnosis.,Liquid chromatography-tandem mass spectrometry (LC-MS/MS), Lung Cancer

Dr. Roumi Deb
contact affiliation	Head, Department of Anthropology, AISS Amity University Uttar Pradesh Sector-125, Noida
contact email	rdev@amity.edu
lab head
Roumi Deb
contact affiliation	Department of Anthropology, Amity Institute of Social Sciences, Amity University Noida
contact email	rdev@amity.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064138
     1. Label: PRIDE project
     2. Name: Salivary Proteomics as a Potential Tool for Early Lung Cancer Detection: Insights from the East Khasi Hills, Meghalaya, India