PXD064132

PXD064132 is an original dataset announced via ProteomeXchange.

Title	Proteomic and transcriptomic profiling identifies TIPRL as a potential target in multiple myeloma with 1q gain
Description	Amplification or gain of chromosome 1q (+1q) is a common genomic alteration occurring in nearly 40% of multiple myeloma patients. Although it is associated with poor prognosis and advanced disease stages, the impact of +1q at the proteomic level remains unclear. Here, we studied sorted CD138+ plasma cells from the bone marrow from newly diagnosed multiple myeloma to uncover molecular alterations associated with +1q. Differential expression analysis revealed significantly increased expression of several proteins encoded by 1q region indicating potential gene dosage effect. Protein pathway enrichment analysis identified enrichment of cell cycle pathway among proteins with increased expression in +1q. Further, protein-protein interaction network analysis showed enrichment of MYC transcriptional targets including increased expression of TIPRL (located on 1q23) in +1q cases. In agreement with these findings, increased TIPRL transcript expression was correlated with +1q across different primary driver genomic alterations in MM in the CoMMPass dataset. High TIPRL protein expression was further associated with poor prognosis in cases with hyperdiploidy. Overall, this study highlights the role of proteomics in understanding molecular events associated with chromosomal alterations in multiple myeloma and identifying potential targets for further functional analysis.
HostingRepository	PRIDE
AnnounceDate	2026-05-14
AnnouncementXML	Submission_2026-05-14_06:59:30.595.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-20 21:22:54	ID requested
⏵ 1	2026-05-14 06:59:31	announced

10.1038/s41698-026-01364-7;

Mangalaparthi KK, Hsu JS, Wiedmeier-Nutor JE, Sen P, Staub J, Bhat FA, Stein CK, Ahmann GJ, Kumar SK, Rajkumar SV, Bergsagel PL, Fonseca R, Braggio E, Kandasamy RK, Pandey A, Proteomic profiling revealed unique disease biology associated with 1q abnormalities in multiple myeloma. NPJ Precis Oncol, ():(2026) [pubmed]

submitter keyword: Plasma cells, MYC, diaPASEF, Cell cycle,Label-free proteomics, CD138

AKhilesh Pandey
contact affiliation	Professor Department of Laboratory Medicine and Pathology Mayo Clinic 200 First Street SW, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
lab head
Akhilesh Pandey
contact affiliation	Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064132
     1. Label: PRIDE project
     2. Name: Proteomic and transcriptomic profiling identifies TIPRL as a potential target in multiple myeloma with 1q gain