PXD064054

PXD064054 is an original dataset announced via ProteomeXchange.

Title	Data from the mass spectrometry analysis of the RhETR3 protein.
Description	Gaseous phytohormone ethylene regulates various aspects of plant development. Ethylene is perceived by ER membrane-localized receptors, which are inactivated upon binding with ethylene molecules, thereby initiating ethylene signal transduction. Here, we report that a novel E3 ligase RING finger for Ethylene receptor Degradation (RED) and its E2 partner UBC32 ubiquitinate ethylene-bound receptors for degradation through an ER associated degradation (ERAD) pathway in both Rosa hybrida and Solanum lycopersicum. The depletion of RED or UBC32 leads to hypersensitivity to ethylene, which is manifested as premature leaf abscission and petal shedding in roses, as well as the dwarf plants and accelerated fruit ripening in tomatoes. Disruption of the conserved ethylene binding site of receptors prevents RED-mediated degradation of the receptors. Our study discovers an ERAD branch that facilitates the ethylene-induced degradation of receptors, and provides insights into how the plant’s response to ethylene can be controlled by modulating the turnover of ethylene receptors
HostingRepository	PRIDE
AnnounceDate	2025-06-06
AnnouncementXML	Submission_2025-06-06_11:00:07.633.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	qingcui zhao
SpeciesList	scientific name: Nicotiana tabacum (Common tobacco); NCBI TaxID: 4097;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-19 03:40:10	ID requested
⏵ 1	2025-06-06 11:00:08	announced

Dataset with its publication pending

submitter keyword: ethylene response,Ethylene receptors, UBC32, ERAD, RED

Nan Ma
contact affiliation	China Agricultural University
contact email	ma_nan@cau.edu.cn
lab head
qingcui zhao
contact affiliation	henzhen Polytechnic University
contact email	zhaoqingcui@szpu.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064054
     1. Label: PRIDE project
     2. Name: Data from the mass spectrometry analysis of the RhETR3 protein.