PXD064042

PXD064042 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis of UUO-14d kidneys from Adamts18+/+ versus Adamts18−/− mice using label-free LC-MS/MS
Description	This project aims to investigate the proteomic differences between Adamts18+/+ and Adamts18−/− mice in response to unilateral ureteral obstruction (UUO) for 14 days. Kidney tissues were collected from both genotypes and subjected to quantitative proteomic analysis using label-free LC-MS/MS-based techniques. The workflow included protein extraction, trypsin digestion, peptide separation, and mass spectrometric analysis. Differentially expressed proteins were identified to explore the molecular mechanisms associated with Adamts18 deficiency in renal fibrosis under UUO conditions.
HostingRepository	iProX
AnnounceDate	2025-05-19
AnnouncementXML	Submission_2025-07-01_23:58:05.886.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Min Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-18 23:39:55	ID requested
1	2025-05-18 23:40:17	announced
⏵ 2	2025-07-01 23:58:06	announced	2025-07-02: Add Publication

Wang M, Xu F, Niu X, Zhang M, Liu H, Hong T, Dang S, Zhang W, to exacerbate renal fibrosis. Commun Biol, 8(1):892(2025) [pubmed]

submitter keyword: Mouse, UUO, Adamts18 knockout, Kidney, 14 days, Label-free Quantitative Proteomics, LC-MS/MS

Wei Zhang
contact affiliation	East China Normal University
contact email	wzhang@sat.ecnu.edu.cn
lab head
Min Wang
contact affiliation	East China Normal University
contact email	52261300023@stu.ecnu.edu.cn
dataset submitter

iProX dataset URI