PXD064037

PXD064037 is an original dataset announced via ProteomeXchange.

Title	Bdh1 regulates high glucose-induced cardiomyocyte apoptosis and diabetic cardiomyopathy by modulating mitochondrial dynamics and attenuating oxidative stress
Description	Diabetic cardiomyopathy (DCM) is a significant cardiovascular complication of chronic diabetes characterized by progressive cardiac dysfunction that can ultimately lead to heart failure and increased mortality. Despite advances in diabetes management, therapeutic options for DCM remain limited, with current treatments focused primarily on glycemic control and symptom management. However, these approaches often fail to address the underlying metabolic and structural abnormalities in the heart. A hallmark of DCM pathogenesis is the elevated rate of cardiomyocyte apoptosis, which contributes to the progressive decline in cardiac function. Emerging evidence suggests that ketone bodies serve as alternative energy substrates for the myocardium in DCM, potentially improving cardiac energy metabolism. Notably, Bdh1 (β-hydroxybutyrate dehydrogenase 1), a rate-limiting enzyme in ketone body metabolism, has been identified as a promising therapeutic target for DCM. However, the specific role of Bdh1 in regulating cardiomyocyte apoptosis in DCM remains poorly understood. Therefore, the aim of this study was to elucidate the role of Bdh1 in modulating cardiomyocyte apoptosis and to explore the underlying molecular mechanisms in the context of DCM.
HostingRepository	iProX
AnnounceDate	2025-05-16
AnnouncementXML	Submission_2025-05-18_21:30:34.665.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	YuXuan Shi
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-18 21:30:07	ID requested
⏵ 1	2025-05-18 21:30:35	announced

Dataset with its publication pending

submitter keyword: Diabetic cardiomyopathy, Apoptosis, Bdh1, KIF1Bβ, Cardioprotection, Apoptosome

Yueran Zhao
contact affiliation	State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University
contact email	yrzhao@sdu.edu.cn
lab head
YuXuan Shi
contact affiliation	State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University
contact email	syx17854221075@163.com
dataset submitter

iProX dataset URI