PXD064004

PXD064004 is an original dataset announced via ProteomeXchange.

Title	OTUD3-Mediated Stabilization of SLC7A11 Drives Sunitinib Resistance by Suppressing Ferroptosis in Clear Cell Renal Cell Carcinoma
Description	After cell lysis, the global proteomes of wild-type 786O and OTUD3-knockdown (KD) 786O cell lines were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Label-free quantification (LFQ) was employed for comparative protein quantification, and tandem mass spectrometry data were acquired in data-dependent acquisition (DDA) mode to prioritize high-abundance precursor ions for fragmentation
HostingRepository	PRIDE
AnnounceDate	2025-08-15
AnnouncementXML	Submission_2025-08-15_04:36:22.349.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tian Xu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-16 01:00:55	ID requested
⏵ 1	2025-08-15 04:36:23	announced

10.1016/j.canlet.2025.217942;

Xu T, Liu H, Ling N, Chen D, Dai J, Chen W, Li Y, Gao X, Zhai W, Ye M, Sun Y, Tan W, OTUD3-mediated stabilization of SLC7A11 drives sunitinib resistance by suppressing ferroptosis in clear cell renal cell carcinoma. Cancer Lett, 632():217942(2025) [pubmed]

submitter keyword: 786O shOTUD3 LC/MSMS

Weihong Tan
contact affiliation	Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
contact email	tan@hnu.edu.cn
lab head
Tian Xu
contact affiliation	Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University
contact email	xutian@mail.ustc.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD064004

PRIDE project URI

• PRIDE
  1. PXD064004
     1. Label: PRIDE project
     2. Name: OTUD3-Mediated Stabilization of SLC7A11 Drives Sunitinib Resistance by Suppressing Ferroptosis in Clear Cell Renal Cell Carcinoma