PXD064002

PXD064002 is an original dataset announced via ProteomeXchange.

Title	Explaining Echis envenoming: Transcriptomic and proteomic profiling of Echis carinatus venom
Description	In India, venom research has largely focussed on the ‘big four’ snakes that are greatly responsible for the burden of snakebite in the Indian subcontinent. This study aims to advance understanding of saw-scaled viper venoms from India, we implemented a multi-faceted approach. We sequenced the venom gland transcriptome of E. carinatus for the first time, while also characterising its venom proteome. This was followed by the evaluation of the biochemical activities of the major toxins in E. carinatus venoms. Finally, we assessed the in vitro binding efficacy and in vivo neutralising potency of commercial antivenoms against E. carinatus
HostingRepository	PRIDE
AnnounceDate	2025-08-04
AnnouncementXML	Submission_2025-08-03_16:23:52.929.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kartik Sunagar
SpeciesList	scientific name: Echis carinatus; NCBI TaxID: 40353;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-16 00:35:03	ID requested
⏵ 1	2025-08-03 16:23:53	announced

Javed S, Gond PG, Samanta A, Unawane A, Mudavath MN, Jaglan A, Sunagar K, Venom. Toxins (Basel), 17(7):(2025) [pubmed]

10.3390/toxins17070353;

submitter keyword: antivenom, in vivo, Proteome,Echis carinatus, Transcriptome

Kartik Sunagar
contact affiliation	Indian Institute of Science, Bangalore
contact email	ksunagar@iisc.ac.in
lab head
Kartik Sunagar
contact affiliation	Assistant Professor, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India.
contact email	ksunagar@iisc.ac.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064002
     1. Label: PRIDE project
     2. Name: Explaining Echis envenoming: Transcriptomic and proteomic profiling of Echis carinatus venom