PXD063928

PXD063928 is an original dataset announced via ProteomeXchange.

Title	Pathological meprin a activity associated with degradation of dermokine drives a psoriasis-like skin phenotype in a novel genetic mouse model
Description	Keratinocyte proliferation and differentiation is regulated via proteolytic networks. Dysregulation of proteases within these systems can cause hyperproliferative and inflammatory skin disorders. In healthy skin the metalloprotease meprin α is localized in the stratum basale, yet in wound healing tissue and psoriatic lesions meprin α is synthesized at higher levels and translocalized to upper epidermal layers. We developed a transgenic mouse model for inducible expression of pathological meprin α levels (K5Mα) to investigate its epidermal degradome and, thereby, identify molecular links to keratinocyte proliferation and skin inflammation.
HostingRepository	PRIDE
AnnounceDate	2026-02-03
AnnouncementXML	Submission_2026-02-03_06:34:54.139.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vahap Canbay
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-14 07:07:36	ID requested
⏵ 1	2026-02-03 06:34:54	announced

Dataset with its publication pending

submitter keyword: Degradomics, DIA,Mouse, psoriasis, TAILS, Dermokine

Sascha Rüffer
contact affiliation	University of Kiel Institute of Biochemistry Unit for Degradomics of the Protease Web Otto-Hahn-Platz 9 24118 Kiel Germany
contact email	srueffer@biochem.uni-kiel.de
lab head
Vahap Canbay
contact affiliation	Technical University of Denmark
contact email	vahcan@dtu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD063928

PRIDE project URI

• PRIDE
  1. PXD063928
     1. Label: PRIDE project
     2. Name: Pathological meprin a activity associated with degradation of dermokine drives a psoriasis-like skin phenotype in a novel genetic mouse model