PXD063893
PXD063893 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Androgenic Effects of 11-oxyandrogens in Castration-Resistant Prostate Cancer |
| Description | Investigations of CRPC cell models demonstrate that 11-ketotestesterone (11KT) and 11-hydroxytestosterone (11OHT) drive robust AR-mediated proliferative responses and significantly modulate gene and protein expression profiles, paralleling canonical androgens. They also exhibit unique transcriptional and post-transcriptional effects that include potential AR-independent pathways. Furthermore, the AR antagonist enzalutamide effectively inhibits their androgenic actions, suggesting they are primarily AR-mediated. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-10-10 |
| AnnouncementXML | Submission_2025-10-10_06:42:09.484.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michele Rouleau |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | CarbamidomethylDTT; Met-loss; Homocysteic_acid |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-13 13:28:21 | ID requested | |
| ⏵ 1 | 2025-10-10 06:42:10 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: DIAnn, CRPC proteomics, 11-oxygenated androgens, androgen receptor, enzalutamide, DatasetType:Proteomics |
Contact List
| Chantal Guillemette | |
|---|---|
| contact affiliation | CHU de Quebec Research Center - Universite Laval |
| contact email | chantal.guillemette@crchudequebec.ulaval.ca |
| lab head | |
| Michele Rouleau | |
| contact affiliation | CHU de Qu�bec Research center |
| contact email | michele.rouleau@crchudequebec.ulaval.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097860/ |
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