PXD063850

PXD063850 is an original dataset announced via ProteomeXchange.

Title	Profiling CTBP2’s genome-wide interactome in murine macrophages in resting state and during LPS-induced inflammation
Description	We profiled the genome-wide interactome of the co-repressor C-terminal binding protein 2 (CTBP2) in primary murine macrophages (BMDM) in vehicle and LPS conditions after 3 h of stimulation. We find that CTBP2 interacts with the transcription factors NF-κB and AP-1 and forms a corepressor complex that involves KDM1A, the NuRD complex and other co-repressors.
HostingRepository	PRIDE
AnnounceDate	2025-06-08
AnnouncementXML	Submission_2025-06-08_00:19:02.560.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Wierer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-12 01:40:18	ID requested
⏵ 1	2025-06-08 00:19:02	announced

Dataset with its publication pending

submitter keyword: LPS, macrophage,CTBP2, inflammation, BMDM, mouse, ChIP-MS

Henriette Uhlenhaut
contact affiliation	Metabolic Programming, TUM School of Life Sciences, Technical University of Munich, Munich, Bavaria, Germany
contact email	henriette.uhlenhaut@tum.de
lab head
Michael Wierer
contact affiliation	Proteomics Research Infrastructure, University of Copenhagen
contact email	michael.wierer@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD063850

PRIDE project URI

• PRIDE
  1. PXD063850
     1. Label: PRIDE project
     2. Name: Profiling CTBP2’s genome-wide interactome in murine macrophages in resting state and during LPS-induced inflammation