PXD063813

PXD063813 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The covalent bonding of beta-2-microglobulin with HLA class I influences the antigenic landscape of cells
Description	Here, we investigate the effect that a constant interaction of beta-2m with HLA-I molecules can have on what antigens and peptides are displayed upon direct- and cross-presentation. When beta-2m is linked to HLA-I molecules the antigenic landscape is modified compared to physiological conditions.
HostingRepository	PRIDE
AnnounceDate	2026-06-04
AnnouncementXML	Submission_2026-06-04_06:00:36.428.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yehor Horokhovskyi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	6220 Time-of-Flight LC/MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-09 08:49:58	ID requested
⏵ 1	2026-06-04 06:00:37	announced

Publication List

10.1002/eji.70210;
Barajas Molina A, Horokhovskyi Y, Acuti N, Chong YK, Phanichkrivalkosil M, Siddons S, Afrache H, Maloney M, Soh WT, Hofland T, Hall C, Urlaub H, Kassiotis G, Liepe J, Mishto M, 2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes. Eur J Immunol, 56(5):e70210(2026) [pubmed]

10.1002/eji.70210;

Barajas Molina A, Horokhovskyi Y, Acuti N, Chong YK, Phanichkrivalkosil M, Siddons S, Afrache H, Maloney M, Soh WT, Hofland T, Hall C, Urlaub H, Kassiotis G, Liepe J, Mishto M, 2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes. Eur J Immunol, 56(5):e70210(2026) [pubmed]

Keyword List

submitter keyword: LC-MSMS,HLA-I, immunopeptidome, MHC-I

submitter keyword: LC-MSMS,HLA-I, immunopeptidome, MHC-I

Contact List

Henning Urlaub
contact affiliation	Bioanalytical Mass Spectrometry Group Max-Planck-Institute for Multidisciplinary Sciences Goettingen, Germany
contact email	henning.urlaub@mpinat.mpg.de
lab head
Yehor Horokhovskyi
contact affiliation	Max-Planck-Institute for Multidisciplinary Sciences
contact email	yehor.horokhovskyi@mpinat.mpg.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD063813
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD063813

PRIDE project URI

Repository Record List

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