PXD063786

PXD063786 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Structural analysis of the CSN complex to understand its inhibition mechanism
Description	We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, cross-linking mass spectrometry, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and structural changes of the CSN complex in vitro and in cells.
HostingRepository	PRIDE
AnnounceDate	2025-11-20
AnnouncementXML	Submission_2025-11-20_09:51:11.360.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fenglong Jiao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-08 21:31:15	ID requested
⏵ 1	2025-11-20 09:51:11	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: CSN, quantitative MS, CRLs, protein ubiquitination, neddylation, XL-MS, Cryo-EM,COP9 signalsome

submitter keyword: CSN, quantitative MS, CRLs, protein ubiquitination, neddylation, XL-MS, Cryo-EM,COP9 signalsome

Contact List

Lan Huang
contact affiliation	Department of Physiology & Biophysics, University of California, Irvine, Irvine, California, USA
contact email	lanhuang@uci.edu
lab head
Fenglong Jiao
contact affiliation	University of California, Irvine
contact email	fenglonj@uci.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063786
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063786

PRIDE project URI

Repository Record List

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