PXD063780

PXD063780 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Title: Demographic Factors Predictive of Skin Barrier Function in a Large Population-Based Study
Description	The skin has a vital role in homeostasis, but there are limited and conflicting data on factors associated with skin barrier function. We evaluated the relationship between participant characteristics and four barrier function measures in a diverse population-based sample of 286 participants ages 32-97 in the Baltimore Longitudinal Study of Aging (BLSA), a well-characterized cohort of healthy aging. Multivariable analysis indicated older age, female sex, Black race/ethnicity, and higher BMI were associated with at least one measure of better barrier function: older age was associated with better dynamic barrier function (beta=-0.141, p=0.034) and barrier permeability (beta=-0.158, p=0.018); female participants had superior dynamic barrier function (beta=0.164, p=0.027) and increased barrier recovery (beta=-0.239, p=0.001); black participants also had better dynamic barrier function (beta=-0.200, p=0.006) and higher barrier integrity (beta=0.256, p<0.001); and higher BMI was associated with better barrier integrity (beta=0.131, p=0.033). Protein expression from tape strips analyzed by mass spectrometry among a sub-sample of 20 participants showed that protein families linked to barrier composition and insult response were higher among participants with above-median barrier function (p<0.01). Our results provide a framework for future research on epidermal barrier function and suggest additional measures are needed to differentiate age-associated barrier decline.
HostingRepository	MassIVE
AnnounceDate	2025-05-08
AnnouncementXML	Submission_2025-05-08_16:07:45.379.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brett Phinney
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-08 15:12:03	ID requested
⏵ 1	2025-05-08 16:07:45	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: skin, skin barrier, Baltimore Longitudinal Study of Aging, Aging, DatasetType:Proteomics

submitter keyword: skin, skin barrier, Baltimore Longitudinal Study of Aging, Aging, DatasetType:Proteomics

Contact List

Katrina Abuabara
contact affiliation	University of California, San Francisco, Department of Dermatology
contact email	katrina.abuabara@ucsf.edu
lab head
Brett Phinney
contact affiliation	UC Davis
contact email	brettsp@ucdavis.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097834/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097834/