PXD063772

PXD063772 is an original dataset announced via ProteomeXchange.

Title	Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling
Description	Beta cell replacement therapy for type 1 diabetes is hindered by poor graft survival and suboptimal function, largely due to inadequate vascularization and lack of supportive microenvironment. To address these challenges, we developed a clinically scalable, extracellular matrix (ECM)–mimetic hydrogel, termed Amniogel, derived from human amniotic membrane via streamlined, clinically compliant process. Co-encapsulation of pancreatic islets with blood outgrowth endothelial cells (BOECs) within Amniogel facilitated the formation of prevascularized endocrine constructs (VECs).
HostingRepository	PRIDE
AnnounceDate	2026-04-24
AnnouncementXML	Submission_2026-04-24_09:23:03.663.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD063772
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Fanny Lebreton
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-08 10:20:25	ID requested
⏵ 1	2026-04-24 09:23:04	announced

10.6019/PXD063772;

submitter keyword: Human, bioartificial pancreas

Ekaterine Berishvili
contact affiliation	Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland
contact email	ekaterine.berishvili@unige.ch
lab head
Fanny Lebreton
contact affiliation	Hopitaux Universitaires de Genève
contact email	fanny.lebreton@unige.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063772

PRIDE project URI

• PRIDE
  1. PXD063772
     1. Label: PRIDE project
     2. Name: Bioengineering of the implantable vascularized endocrine constructs for insulin delivery suitable for clinical upscaling