PXD063691

PXD063691 is an original dataset announced via ProteomeXchange.

Title	Photocatalytic Proximity Labeling for Mapping Lysosomal Proteome
Description	This project develops the photocatalytic lysosome-tracking proteome mapping (PLT-PM) method, which uses LysoTracker DND-26 as both a lysosomal tracker and visible-light photocatalyst. The method enables one-step, high-resolution, and low-disruption profiling of the lysosomal proteome without requiring genetic modification or custom dye synthesis. It was applied alongside LC-MS/MS to analyze lysosomal proteome changes during rapamycin and amino acid starvation-induced autophagy, offering a biocompatible and accessible platform to advance lysosome-related research.
HostingRepository	iProX
AnnounceDate	2025-05-03
AnnouncementXML	Submission_2025-05-06_20:05:23.802.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liang Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-06 20:05:02	ID requested
⏵ 1	2025-05-06 20:05:24	announced

Dataset with its publication pending

submitter keyword: photocatalysis, proximity Labeling, proteomics, lysosome

Liang Zhang
contact affiliation	City University of Hong Kong
contact email	liangzhang.28@cityu.edu.hk
lab head
Liang Zhang
contact affiliation	City University of Hong Kong
contact email	liangzhang.28@cityu.edu.hk
dataset submitter

iProX dataset URI