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PXD063691

PXD063691 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePhotocatalytic Proximity Labeling for Mapping Lysosomal Proteome
DescriptionThis project develops the photocatalytic lysosome-tracking proteome mapping (PLT-PM) method, which uses LysoTracker DND-26 as both a lysosomal tracker and visible-light photocatalyst. The method enables one-step, high-resolution, and low-disruption profiling of the lysosomal proteome without requiring genetic modification or custom dye synthesis. It was applied alongside LC-MS/MS to analyze lysosomal proteome changes during rapamycin and amino acid starvation-induced autophagy, offering a biocompatible and accessible platform to advance lysosome-related research.
HostingRepositoryiProX
AnnounceDate2025-05-03
AnnouncementXMLSubmission_2025-05-06_20:05:23.802.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLiang Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-05-06 20:05:02ID requested
12025-05-06 20:05:24announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: photocatalysis, proximity Labeling, proteomics, lysosome
Contact List
Liang Zhang
contact affiliationCity University of Hong Kong
contact emailliangzhang.28@cityu.edu.hk
lab head
Liang Zhang
contact affiliationCity University of Hong Kong
contact emailliangzhang.28@cityu.edu.hk
dataset submitter
Full Dataset Link List
iProX dataset URI